Replication-incompetent influenza A viruses armed with IFN-γ effectively mediate immune modulation and tumor destruction in mice harboring lung cancer

Low pathogenic influenza A viruses (IAVs) have shown promising oncolytic potential in lung cancer–bearing mice. However, as replication-competent pathogens, they may cause side effects in immunocompromised cancer patients. To circumvent this problem, we genetically engineered nonreplicating IAVs lac...

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Detalles Bibliográficos
Autores principales: Meissner, Ramona, Wixler, Viktor, Wulfert, Franziska Paulina, Jacob, Jasmin Carina, Hale, Benjamin G., Robeck, Thomas, Masemann, Dörthe, Boergeling, Yvonne, Ludwig, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679949/
https://www.ncbi.nlm.nih.gov/pubmed/38020062
http://dx.doi.org/10.1016/j.omto.2023.100741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679949/
https://www.ncbi.nlm.nih.gov/pubmed/38020062
http://dx.doi.org/10.1016/j.omto.2023.100741

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