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Anti-TIM3 chimeric antigen receptor-natural killer cells from engineered induced pluripotent stem cells effectively target acute myeloid leukemia cells

BACKGROUND: Acute myeloid leukemia (AML) is a clonal malignant disorder which originates from a small number of leukemia-initiating cells or leukemic stem cells (LSCs)—the subpopulation that is also the root cause of relapsed/refractory AML. Chimeric antigen receptor (CAR)-T cell therapy has proved...

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Detalles Bibliográficos
Autores principales:	Klaihmon, Phatchanat, Luanpitpong, Sudjit, Kang, Xing, Issaragrisil, Surapol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680184/ https://www.ncbi.nlm.nih.gov/pubmed/38012684 http://dx.doi.org/10.1186/s12935-023-03153-9

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