EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A

BACKGROUND: Epigenetic alterations play an important role in hepatocellular carcinoma (HCC) development. Enhancer of zeste homolog 2 (EZH2) is a well-known epigenetic modifier that functions as an oncogene in tumors by promoting the H3K27me3-mediated transcriptional repression of tumor suppressor ge...

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Detalles Bibliográficos
Autores principales: Wang, Ke, Jiang, Xunliang, Jiang, Yu, Liu, Jun, Du, Yongtao, Zhang, Zecheng, Li, Yunlong, Zhao, Xinhui, Li, Jipeng, Zhang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680220/
https://www.ncbi.nlm.nih.gov/pubmed/38008711
http://dx.doi.org/10.1186/s13046-023-02855-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680220/
https://www.ncbi.nlm.nih.gov/pubmed/38008711
http://dx.doi.org/10.1186/s13046-023-02855-2

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