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EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A

BACKGROUND: Epigenetic alterations play an important role in hepatocellular carcinoma (HCC) development. Enhancer of zeste homolog 2 (EZH2) is a well-known epigenetic modifier that functions as an oncogene in tumors by promoting the H3K27me3-mediated transcriptional repression of tumor suppressor ge...

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Detalles Bibliográficos
Autores principales:	Wang, Ke, Jiang, Xunliang, Jiang, Yu, Liu, Jun, Du, Yongtao, Zhang, Zecheng, Li, Yunlong, Zhao, Xinhui, Li, Jipeng, Zhang, Rui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680220/ https://www.ncbi.nlm.nih.gov/pubmed/38008711 http://dx.doi.org/10.1186/s13046-023-02855-2

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