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Single VHH-directed BCMA CAR-NK cells for multiple myeloma

Natural killer (NK) cells are promising alternatives for the production of “off-the-shelf” CAR products, posing a lower risk of cytokine release syndrome (CRS) than CAR-T cells. We synthesized four single VHH-directed anti-BCMA CARs, incorporating various intracellular regions (2B4 versus CD28) and...

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Detalles Bibliográficos
Autores principales: Ren, Quan, Zu, Yingling, Su, Hongchang, Lu, Qiumei, Xiang, Bin, Luo, Yanping, Zhang, Jishuai, Song, Yongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680242/
https://www.ncbi.nlm.nih.gov/pubmed/38012722
http://dx.doi.org/10.1186/s40164-023-00461-8