Upregulated expression of miR-4443 and miR-4488 in drug resistant melanomas promotes migratory and invasive phenotypes through downregulation of intermediate filament nestin

BACKGROUND: BRAF-mutant melanoma patients benefit from the combinatorial treatments with BRAF and MEK inhibitors. However, acquired drug resistance strongly limits the efficacy of these targeted therapies in time. Recently, many findings have underscored the involvement of microRNAs as main drivers...

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Detalles Bibliográficos
Autores principales: Castaldo, Vittorio, Minopoli, Michele, Di Modugno, Francesca, Sacconi, Andrea, Liguoro, Domenico, Frigerio, Rachele, Ortolano, Arianna, Di Martile, Marta, Gesualdi, Luisa, Madonna, Gabriele, Capone, Mariaelena, Cirombella, Roberto, Catizone, Angiolina, Del Bufalo, Donatella, Vecchione, Andrea, Carriero, Maria Vincenza, Ascierto, Paolo Antonio, Mancini, Rita, Fattore, Luigi, Ciliberto, Gennaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680267/
https://www.ncbi.nlm.nih.gov/pubmed/38008717
http://dx.doi.org/10.1186/s13046-023-02878-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680267/
https://www.ncbi.nlm.nih.gov/pubmed/38008717
http://dx.doi.org/10.1186/s13046-023-02878-9

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