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GITR and TIGIT immunotherapy provokes divergent multicellular responses in the tumor microenvironment of gastrointestinal cancers
BACKGROUND: Understanding the mechanistic effects of novel immunotherapy agents is critical to improving their successful clinical translation. These effects need to be studied in preclinical models that maintain the heterogenous tumor microenvironment (TME) and dysfunctional cell states found in a...
Autores principales: | Sathe, Anuja, Ayala, Carlos, Bai, Xiangqi, Grimes, Susan M., Lee, Byrne, Kin, Cindy, Shelton, Andrew, Poultsides, George, Ji, Hanlee P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680277/ https://www.ncbi.nlm.nih.gov/pubmed/38008725 http://dx.doi.org/10.1186/s13073-023-01259-3 |
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