Computational Modeling of Stapled Coiled-Coil Inhibitors Against Bcr-Abl: Toward a Treatment Strategy for CML

The chimeric oncoprotein Bcr-Abl is the causative agent of virtually all chronic myeloid leukemias (CML) and a subset of acute lymphoblastic leukemias (ALL). As a result of the so-called Philadelphia Chromosome translocation t(9;22), Bcr-Abl manifests as a constitutively active tyrosine kinase which...

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Detalles Bibliográficos
Autores principales: Lima, Maria Carolina P., Hornsby, Braxten D., Lim, Carol S., Cheatham, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680756/
https://www.ncbi.nlm.nih.gov/pubmed/38014060
http://dx.doi.org/10.1101/2023.11.15.566894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680756/
https://www.ncbi.nlm.nih.gov/pubmed/38014060
http://dx.doi.org/10.1101/2023.11.15.566894

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