Suppressing DNMT3a Alleviates the Intrinsic Epigenetic Barrier for Optic Nerve Regeneration and Restores Vision in Adult Mice

The limited regenerative potential of the optic nerve in adult mammals presents a major challenge for restoring vision after optic nerve trauma or disease. The mechanisms of this regenerative failure are not fully understood(1,2). Here, through small-molecule and genetic screening for epigenetic mod...

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Detalles Bibliográficos
Autores principales: Tai, Wai Lydia, Cho, Kin-Sang, Kriukov, Emil, Ashok, Ajay, Wang, Xuejian, Monavarfeshani, Aboozar, Yan, Wenjun, Li, Yingqian, Guan, Timothy, Sanes, Joshua R., Baranov, Petr, Chen, Dong Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680854/
https://www.ncbi.nlm.nih.gov/pubmed/38014168
http://dx.doi.org/10.1101/2023.11.17.567614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680854/
https://www.ncbi.nlm.nih.gov/pubmed/38014168
http://dx.doi.org/10.1101/2023.11.17.567614

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