Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoids

Background: Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain, and a significant decrease in quality of life. Among other risk factors, such as genetics and age, hyper-physiological mechanical c...

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Detalles Bibliográficos
Autores principales: Bloks, Niek GC, Dicks, Amanda, Harissa, Zainab, Nelissen, Rob GHH, Hajmousa, Ghazaleh, Ramos, Yolande FM, Almeida, Rodrigo Coutinho, Guilak, Farshid, Meulenbelt, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680909/
https://www.ncbi.nlm.nih.gov/pubmed/38014245
http://dx.doi.org/10.21203/rs.3.rs-3568544/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680909/
https://www.ncbi.nlm.nih.gov/pubmed/38014245
http://dx.doi.org/10.21203/rs.3.rs-3568544/v1

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