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Checkpoint phosphorylation sites on budding yeast Rif1 protect nascent DNA from degradation by Sgs1-Dna2

In budding yeast the Rif1 protein is important for protecting nascent DNA at blocked replication forks, but the mechanism has been unclear. Here we show that budding yeast Rif1 must interact with Protein Phosphatase 1 to protect nascent DNA. In the absence of Rif1, removal of either Dna2 or Sgs1 pre...

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Detalles Bibliográficos
Autores principales: Gali, Vamsi Krishna, Monerawela, Chandre, Laksir, Yassine, Hiraga, Shin-ichiro, Donaldson, Anne D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681312/
https://www.ncbi.nlm.nih.gov/pubmed/37956214
http://dx.doi.org/10.1371/journal.pgen.1011044