A model‐based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno‐oncology

FAP‐4‐1BBL is a bispecific antibody exerting 4‐1BB‐associated T‐cell activation only while simultaneously bound to the fibroblast activation protein (FAP) receptor, expressed on the surface of cancer‐associated fibroblasts. The trimeric complex formed when FAP‐4‐1BBL is simultaneously bound to FAP a...

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Detalles Bibliográficos
Autores principales: Sánchez, Javier, Claus, Christina, Albrecht, Rosmarie, Gaillard, Brenda C., Marinho, Joana, McIntyre, Christine, Tanos, Tamara, Boehnke, Axel, Friberg, Lena E., Jönsson, Siv, Frances, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681425/
https://www.ncbi.nlm.nih.gov/pubmed/37964753
http://dx.doi.org/10.1002/psp4.13065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681425/
https://www.ncbi.nlm.nih.gov/pubmed/37964753
http://dx.doi.org/10.1002/psp4.13065

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