Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids

In various autoimmune diseases, dysfunctional TREX1 (Three prime Repair Exonuclease 1) leads to accumulation of endogenous single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and DNA/RNA hybrids in the cytoplasm and triggers immune activation through the cGAS–STING pathway. Although inhibition...

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Detalles Bibliográficos
Autores principales: Huang, Kuan-Wei, Wu, Chia-Yun, Toh, Shu-Ing, Liu, Tung-Chang, Tu, Chun-I, Lin, Yin-Hsin, Cheng, An-Ju, Kao, Ya-Ting, Chu, Jhih-Wei, Hsiao, Yu-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681709/
https://www.ncbi.nlm.nih.gov/pubmed/37870446
http://dx.doi.org/10.1093/nar/gkad910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681709/
https://www.ncbi.nlm.nih.gov/pubmed/37870446
http://dx.doi.org/10.1093/nar/gkad910

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