Cargando…

Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids

In various autoimmune diseases, dysfunctional TREX1 (Three prime Repair Exonuclease 1) leads to accumulation of endogenous single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and DNA/RNA hybrids in the cytoplasm and triggers immune activation through the cGAS–STING pathway. Although inhibition...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Kuan-Wei, Wu, Chia-Yun, Toh, Shu-Ing, Liu, Tung-Chang, Tu, Chun-I, Lin, Yin-Hsin, Cheng, An-Ju, Kao, Ya-Ting, Chu, Jhih-Wei, Hsiao, Yu-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681709/ https://www.ncbi.nlm.nih.gov/pubmed/37870446 http://dx.doi.org/10.1093/nar/gkad910

Ejemplares similares

Structural insights into the duplex DNA processing of TREX2
por: Cheng, Hiu-Lo, et al.
Publicado: (2018)

Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
por: Huang, Kuan-Wei, et al.
Publicado: (2018)

Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex
por: Gordon, James M. B., et al.
Publicado: (2017)

Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export
por: Jani, Divyang, et al.
Publicado: (2014)

Gbp2 interacts with THO/TREX through a novel type of RRM domain
por: Martínez-Lumbreras, Santiago, et al.
Publicado: (2016)

Structural insights into RNA unwinding and degradation by RNase R
por: Chu, Lee-Ya, et al.
Publicado: (2017)

Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA
por: Chi, Binkai, et al.
Publicado: (2013)

Crystal structure of dimeric human PNPase reveals why disease-linked mutants suffer from low RNA import and degradation activities
por: Golzarroshan, Bagher, et al.
Publicado: (2018)

Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation
por: Lin, Chia Liang, et al.
Publicado: (2012)

Yeast Ssd1 is a non-enzymatic member of the RNase II family with an alternative RNA recognition site
por: Bayne, Rosemary A, et al.
Publicado: (2021)

Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2
por: Xie, Yihu, et al.
Publicado: (2021)

Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states
por: Shen, Ning, et al.
Publicado: (2008)

TREX exposes the RNA binding domain of Nxf1 to enable mRNA export
por: Viphakone, Nicolas, et al.
Publicado: (2012)

Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control
por: Zheng, Ke-wei, et al.
Publicado: (2013)

Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid
por: Nowak, Elżbieta, et al.
Publicado: (2013)

Structures of mammalian GLD-2 proteins reveal molecular basis of their functional diversity in mRNA and microRNA processing
por: Ma, Xiao-Yan, et al.
Publicado: (2020)

MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
por: Wilson, RaeAnna, et al.
Publicado: (2016)

Differential stability of 2′F-ANA•RNA and ANA•RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility
por: Watts, Jonathan K., et al.
Publicado: (2010)

A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site
por: Zheng, Ke-wei, et al.
Publicado: (2014)

Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing
por: Li, Chia-Lung, et al.
Publicado: (2008)

Structural basis for recognition of G-1-containing tRNA by histidyl-tRNA synthetase
por: Tian, Qingnan, et al.
Publicado: (2015)

U2AF(65) adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs
por: Jenkins, Jermaine L., et al.
Publicado: (2013)

Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
por: Aksenova, Vasilisa, et al.
Publicado: (2020)

Structural probing of the HIV-1 polypurine tract RNA:DNA hybrid using classic nucleic acid ligands
por: Turner, Kevin B., et al.
Publicado: (2008)

Atypical structures of GAA/TTC trinucleotide repeats underlying Friedreich’s ataxia: DNA triplexes and RNA/DNA hybrids
por: Zhang, Jiahui, et al.
Publicado: (2020)

The Interaction of Bluetongue Virus VP6 and Genomic RNA Is Essential for Genome Packaging
por: Sung, Po-Yu, et al.
Publicado: (2019)

Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element
por: Li, Yi-Chuan, et al.
Publicado: (2014)

Mediator and TREX-2: Emerging links between transcription initiation and mRNA export
por: Schubert, Tobias, et al.
Publicado: (2016)

The m(6)A-methylase complex recruits TREX and regulates mRNA export
por: Lesbirel, Simon, et al.
Publicado: (2018)

Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex
por: Kucej, Martin, et al.
Publicado: (2017)

Intact RNA structurome reveals mRNA structure-mediated regulation of miRNA cleavage in vivo
por: Yang, Minglei, et al.
Publicado: (2020)

New insights into the enzymatic role of EF-G in ribosome recycling
por: Zhang, Dejiu, et al.
Publicado: (2015)

Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5′ triphosphate
por: Lu, Cheng, et al.
Publicado: (2011)

In vitro selected GUAA tetraloop-binding receptors with structural plasticity and evolvability towards natural RNA structural modules
por: Zakrevsky, Paul, et al.
Publicado: (2021)

A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication
por: Wu, Chyuan-Chuan, et al.
Publicado: (2019)

Recurrent RNA motifs as probes for studying RNA-protein interactions in the ribosome
por: Gagnon, Matthieu G., et al.
Publicado: (2010)

Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila
por: Hur, Junho K., et al.
Publicado: (2016)

A DNA G-quadruplex/i-motif hybrid
por: Chu, Betty, et al.
Publicado: (2019)

Recruitment of TREX to the Transcription Machinery by Its Direct Binding to the Phospho-CTD of RNA Polymerase II
por: Meinel, Dominik M., et al.
Publicado: (2013)

1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex
por: Valkov, Eugene, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_th34rifkael4c75m71h4oohbu3