BRD9-mediated control of the TGF-β/Activin/Nodal pathway regulates self-renewal and differentiation of human embryonic stem cells and progression of cancer cells

Bromodomain-containing protein 9 (BRD9) is a specific subunit of the non-canonical SWI/SNF (ncBAF) chromatin-remodeling complex, whose function in human embryonic stem cells (hESCs) remains unclear. Here, we demonstrate that impaired BRD9 function reduces the self-renewal capacity of hESCs and alter...

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Detalles Bibliográficos
Autores principales: Wang, Xuepeng, Song, Chengcheng, Ye, Ying, Gu, Yashi, Li, Xuemei, Chen, Peixin, Leng, Dongliang, Xiao, Jing, Wu, Hao, Xie, Sisi, Liu, Weiwei, Zhao, Qi, Chen, Di, Chen, Xi, Wu, Qiang, Chen, Guokai, Zhang, Wensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681724/
https://www.ncbi.nlm.nih.gov/pubmed/37870468
http://dx.doi.org/10.1093/nar/gkad907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681724/
https://www.ncbi.nlm.nih.gov/pubmed/37870468
http://dx.doi.org/10.1093/nar/gkad907

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