Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops

Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis, therapy resistance and metastasis. Radiobiological hypoxia (<0.1% O(2)) is one of the few physiologically relevant stresses that activates both the replication stress/DNA damage response and the unfolded pr...

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Detalles Bibliográficos
Autores principales: Ma, Tiffany S, Worth, Katja R, Maher, Conor, Ng, Natalie, Beghè, Chiara, Gromak, Natalia, Rose, Anna M, Hammond, Ester M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681727/
https://www.ncbi.nlm.nih.gov/pubmed/37843099
http://dx.doi.org/10.1093/nar/gkad858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681727/
https://www.ncbi.nlm.nih.gov/pubmed/37843099
http://dx.doi.org/10.1093/nar/gkad858

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