Cargando…
Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops
Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis, therapy resistance and metastasis. Radiobiological hypoxia (<0.1% O(2)) is one of the few physiologically relevant stresses that activates both the replication stress/DNA damage response and the unfolded pr...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681727/ https://www.ncbi.nlm.nih.gov/pubmed/37843099 http://dx.doi.org/10.1093/nar/gkad858 |