A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA

RIG-I is a cytosolic receptor of viral RNA essential for the immune response to numerous RNA viruses. Accordingly, RIG-I must sensitively detect viral RNA yet tolerate abundant self-RNA species. The basic binding cleft and an aromatic amino acid of the RIG-I C-terminal domain(CTD) mediate high-affin...

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Detalles Bibliográficos
Autores principales: de Regt, Ann Kristin, Anand, Kanchan, Ciupka, Katrin, Bender, Felix, Gatterdam, Karl, Putschli, Bastian, Fusshöller, David, Hilbig, Daniel, Kirchhoff, Alexander, Hunkler, Charlotte, Wolter, Steven, Grünewald, Agathe, Wallerath, Christina, Schuberth-Wagner, Christine, Ludwig, Janos, Paeschke, Katrin, Bartok, Eva, Hagelueken, Gregor, Hartmann, Gunther, Zillinger, Thomas, Geyer, Matthias, Schlee, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681732/
https://www.ncbi.nlm.nih.gov/pubmed/37831086
http://dx.doi.org/10.1093/nar/gkad835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681732/
https://www.ncbi.nlm.nih.gov/pubmed/37831086
http://dx.doi.org/10.1093/nar/gkad835

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