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Model-based characterization of the equilibrium dynamics of transcription initiation and promoter-proximal pausing in human cells
In metazoans, both transcription initiation and the escape of RNA polymerase (RNAP) from promoter-proximal pausing are key rate-limiting steps in gene expression. These processes play out at physically proximal sites on the DNA template and appear to influence one another through steric interactions...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681744/ https://www.ncbi.nlm.nih.gov/pubmed/37889042 http://dx.doi.org/10.1093/nar/gkad843 |