Model-based characterization of the equilibrium dynamics of transcription initiation and promoter-proximal pausing in human cells

In metazoans, both transcription initiation and the escape of RNA polymerase (RNAP) from promoter-proximal pausing are key rate-limiting steps in gene expression. These processes play out at physically proximal sites on the DNA template and appear to influence one another through steric interactions...

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Detalles Bibliográficos
Autores principales: Zhao, Yixin, Liu, Lingjie, Hassett, Rebecca, Siepel, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681744/
https://www.ncbi.nlm.nih.gov/pubmed/37889042
http://dx.doi.org/10.1093/nar/gkad843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681744/
https://www.ncbi.nlm.nih.gov/pubmed/37889042
http://dx.doi.org/10.1093/nar/gkad843

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