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Model-based characterization of the equilibrium dynamics of transcription initiation and promoter-proximal pausing in human cells

In metazoans, both transcription initiation and the escape of RNA polymerase (RNAP) from promoter-proximal pausing are key rate-limiting steps in gene expression. These processes play out at physically proximal sites on the DNA template and appear to influence one another through steric interactions...

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Detalles Bibliográficos
Autores principales:	Zhao, Yixin, Liu, Lingjie, Hassett, Rebecca, Siepel, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Methods
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681744/ https://www.ncbi.nlm.nih.gov/pubmed/37889042 http://dx.doi.org/10.1093/nar/gkad843

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