mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia

Targeted deletion of Raptor, a component of mechanistic target of rapamycin complex 1 (mTORC1), reveals an essential role for mTORC1 in initiation/maintenance of leukemia in a CLL model, resulting from a failure for haemopoietic stem/progenitor cells (HSPCs) to commit to the B cell lineage. Inductio...

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Detalles Bibliográficos
Autores principales: Malik, Natasha, Hay, Jodie, Almuhanna, Hassan N. B., Dunn, Karen M., Lees, Jamie, Cassels, Jennifer, Li, Jiatian, Nakagawa, Rinako, Sansom, Owen J., Michie, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681897/
https://www.ncbi.nlm.nih.gov/pubmed/37775560
http://dx.doi.org/10.1038/s41375-023-02043-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681897/
https://www.ncbi.nlm.nih.gov/pubmed/37775560
http://dx.doi.org/10.1038/s41375-023-02043-3

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