Idasanutlin and navitoclax induce synergistic apoptotic cell death in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy in which activating mutations in the Notch pathway are thought to contribute to transformation, in part, by activating c-Myc. Increased c-Myc expression induces oncogenic stress that can trigger apoptosis through the...

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Detalles Bibliográficos
Autores principales: Johansson, Kimberly B., Zimmerman, Megan S., Dmytrenko, Iryna V., Gao, Feng, Link, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681904/
https://www.ncbi.nlm.nih.gov/pubmed/37838759
http://dx.doi.org/10.1038/s41375-023-02057-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681904/
https://www.ncbi.nlm.nih.gov/pubmed/37838759
http://dx.doi.org/10.1038/s41375-023-02057-x

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