2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition

2-Hydroxyglutarate (2-HG) is an oncometabolite that accumulates in certain cancers. Gain-of-function mutations in isocitrate dehydrogenase lead to 2-HG accumulation at the expense of alpha-ketoglutarate. Elevated 2-HG levels inhibit histone and DNA demethylases, causing chromatin structure and gene...

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Detalles Bibliográficos
Autores principales: Gavriil, Marios, Proietto, Marco, Paczia, Nicole, Ginolhac, Aurelien, Halder, Rashi, Valceschini, Elena, Sauter, Thomas, Linster, Carole L, Sinkkonen, Lasse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681907/
https://www.ncbi.nlm.nih.gov/pubmed/38011998
http://dx.doi.org/10.26508/lsa.202302333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681907/
https://www.ncbi.nlm.nih.gov/pubmed/38011998
http://dx.doi.org/10.26508/lsa.202302333

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