A dual-targeted drug inhibits cardiac ryanodine receptor Ca(2+) leak but activates SERCA2a Ca(2+) uptake

In the heart, genetic or acquired mishandling of diastolic [Ca(2+)] by ryanodine receptor type 2 (RyR2) overactivity correlates with risks of arrhythmia and sudden cardiac death. Strategies to avoid these risks include decrease of Ca(2+) release by drugs modulating RyR2 activity or increase in Ca(2+...

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Detalles Bibliográficos
Autores principales: Wegener, Jörg W, Mitronova, Gyuzel Y, ElShareif, Lina, Quentin, Christine, Belov, Vladimir, Pochechueva, Tatiana, Hasenfuss, Gerd, Ackermann, Lutz, Lehnart, Stephan E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681910/
https://www.ncbi.nlm.nih.gov/pubmed/38012000
http://dx.doi.org/10.26508/lsa.202302278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681910/
https://www.ncbi.nlm.nih.gov/pubmed/38012000
http://dx.doi.org/10.26508/lsa.202302278

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