Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration

Synaptotagmin-1 and synaptotagmin-7 are two prominent calcium sensors that regulate exocytosis in neuronal and neuroendocrine cells. Upon binding calcium, both proteins partially penetrate lipid bilayers that bear anionic phospholipids, but the specific underlying mechanisms that enable them to trig...

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Detalles Bibliográficos
Autores principales: Courtney, Kevin C., Mandal, Taraknath, Mehta, Nikunj, Wu, Lanxi, Li, Yueqi, Das, Debasis, Cui, Qiang, Chapman, Edwin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681989/
https://www.ncbi.nlm.nih.gov/pubmed/38012142
http://dx.doi.org/10.1038/s41467-023-42497-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681989/
https://www.ncbi.nlm.nih.gov/pubmed/38012142
http://dx.doi.org/10.1038/s41467-023-42497-8

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