Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain

A common perception in age-related neurodegenerative diseases posits that a decline in proteostasis is key to the accumulation of neuropathogenic proteins, such as amyloid beta (Aβ), and the development of sporadic Alzheimer’s disease (AD). To experimentally challenge the role of protein homeostasis...

Descripción completa

Detalles Bibliográficos
Autores principales: Santhosh Kumar, Harshitha, Moore, James, Steiner, Adrian C., Sotirakis, Emmanuel, Schärli, Benjamin, Isnard-Petit, Patricia, Thiam, Kader, Wolfer, David P., Böttger, Erik C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682081/
https://www.ncbi.nlm.nih.gov/pubmed/38010524
http://dx.doi.org/10.1007/s00018-023-05031-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682081/
https://www.ncbi.nlm.nih.gov/pubmed/38010524
http://dx.doi.org/10.1007/s00018-023-05031-z

Ejemplares similares