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Deep learning untangles the resistance mechanism of p53 reactivator in lung cancer cells

Tumor suppressor p53 plays a pivotal role in suppressing cancer, so various drugs has been suggested to upregulate its function. However, drug resistance is still the biggest hurdle to be overcome. To address this, we developed a deep learning model called AnoDAN (anomalous gene detection using gene...

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Detalles Bibliográficos
Autores principales: Lee, Soo Min, Han, Younghyun, Cho, Kwang-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682260/
https://www.ncbi.nlm.nih.gov/pubmed/38034356
http://dx.doi.org/10.1016/j.isci.2023.108377