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Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex
The identification and characterization of enzyme function is largely lacking behind the rapidly increasing availability of large numbers of sequences and associated high-resolution structures. This is often hampered by lack of knowledge on in vivo relevant substrates. Here, we present a case study...
Autores principales: | Pinotsis, Nikos, Krüger, Anna, Tomas, Nicolas, Chatziefthymiou, Spyros D., Litz, Claudia, Mortensen, Simon Arnold, Daffé, Mamadou, Marrakchi, Hedia, Antranikian, Garabed, Wilmanns, Matthias |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682391/ https://www.ncbi.nlm.nih.gov/pubmed/38012138 http://dx.doi.org/10.1038/s41467-023-43354-4 |
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