Structural modeling of hERG channel–drug interactions using Rosetta

The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target. Genetic hERG mutations and blockage of the channel pore by drugs can cause long QT syndrome, which...

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Detalles Bibliográficos
Autores principales: Emigh Cortez, Aiyana M., DeMarco, Kevin R., Furutani, Kazuharu, Bekker, Slava, Sack, Jon T., Wulff, Heike, Clancy, Colleen E., Vorobyov, Igor, Yarov-Yarovoy, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682396/
https://www.ncbi.nlm.nih.gov/pubmed/38035013
http://dx.doi.org/10.3389/fphar.2023.1244166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682396/
https://www.ncbi.nlm.nih.gov/pubmed/38035013
http://dx.doi.org/10.3389/fphar.2023.1244166

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