DNA polymerase ε harmonizes topological states and R-loops formation to maintain genome integrity in Arabidopsis

Genome topology is tied to R-loop formation and genome stability. However, the regulatory mechanism remains to be elucidated. By establishing a system to sense the connections between R-loops and genome topology states, we show that inhibiting DNA topoisomerase 1 (TOP1i) triggers the global increase...

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Detalles Bibliográficos
Autores principales: Li, Qin, Zhou, Jincong, Li, Shuai, Zhang, Weifeng, Du, Yingxue, Li, Kuan, Wang, Yingxiang, Sun, Qianwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682485/
https://www.ncbi.nlm.nih.gov/pubmed/38012183
http://dx.doi.org/10.1038/s41467-023-43680-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682485/
https://www.ncbi.nlm.nih.gov/pubmed/38012183
http://dx.doi.org/10.1038/s41467-023-43680-7

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