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DNA polymerase ε harmonizes topological states and R-loops formation to maintain genome integrity in Arabidopsis
Genome topology is tied to R-loop formation and genome stability. However, the regulatory mechanism remains to be elucidated. By establishing a system to sense the connections between R-loops and genome topology states, we show that inhibiting DNA topoisomerase 1 (TOP1i) triggers the global increase...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682485/ https://www.ncbi.nlm.nih.gov/pubmed/38012183 http://dx.doi.org/10.1038/s41467-023-43680-7 |