Loss of Ca(2+) entry via Orai–TRPC1 induces ER stress, initiating immune activation in macrophages

Activation of cellular stresses is associated with inflammation; however, the mechanisms are not well identified. Here, we provide evidence that loss of Ca(2+) influx induces endoplasmic reticulum (ER) stress in primary macrophages and in murine macrophage cell line Raw 264.7, in which the unfolded...

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Detalles Bibliográficos
Autores principales: Nascimento Da Conceicao, Viviane, Sun, Yuyang, Zboril, Emily K., De la Chapa, Jorge J., Singh, Brij B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682644/
https://www.ncbi.nlm.nih.gov/pubmed/31722977
http://dx.doi.org/10.1242/jcs.237610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682644/
https://www.ncbi.nlm.nih.gov/pubmed/31722977
http://dx.doi.org/10.1242/jcs.237610

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