Protection against Aβ-induced neuronal damage by KU-32: PDHK1 inhibition as important target

A feature of most neurodegenerative diseases is the presence of “mis-folded proteins” that form aggregates, suggesting suboptimal activity of neuronal molecular chaperones. Heat shock protein 90 (Hsp90) is the master regulator of cell responses to “proteotoxic” stresses. Some Hsp90 modulators activa...

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Detalles Bibliográficos
Autores principales: Pal, Ranu, Hui, Dongwei, Menchen, Heather, Zhao, Huiping, Mozziconacci, Olivier, Wilkins, Heather, Blagg, Brian S. J., Schöneich, Christian, Swerdlow, Russell H., Michaelis, Mary L., Michaelis, Elias K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682733/
https://www.ncbi.nlm.nih.gov/pubmed/38035268
http://dx.doi.org/10.3389/fnagi.2023.1282855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682733/
https://www.ncbi.nlm.nih.gov/pubmed/38035268
http://dx.doi.org/10.3389/fnagi.2023.1282855

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