Cargando…

Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application

In this study, The inhibitory actions of human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII are being examined using recently synthesized substituted hydroxyl Schiff derivatives based on the quinazoline scaffold 4–22. Quinazolines 2, 3, 4, 5, 7, 10, 15, and 18 reduce the act...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Azab, Adel S., A.-M. Abdel-Aziz, Alaa, Bua, Silvia, Nocentini, Alessio, Bakheit, Ahmed H., Alkahtani, Hamad M., Hefnawy, Mohamed M., Supuran, Claudiu T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682911/ https://www.ncbi.nlm.nih.gov/pubmed/38033749 http://dx.doi.org/10.1016/j.jsps.2023.101866

Ejemplares similares

Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide
por: El-Azab, Adel S., et al.
Publicado: (2022)

Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights
por: Abdelrahman, Mohamed A., et al.
Publicado: (2019)

Activation of human α-carbonic anhydrase isoforms I, II, IV and VII with bis-histamine schiff bases and bis-spinaceamine substituted derivatives
por: Akocak, Suleyman, et al.
Publicado: (2019)

Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates
por: El-Gazzar, Marwa G., et al.
Publicado: (2018)

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation
por: Anduran, Emilie, et al.
Publicado: (2020)

Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides
por: Angeli, Andrea, et al.
Publicado: (2023)

Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors
por: El-Azab, Adel S., et al.
Publicado: (2020)

Benzenesulfonamides Incorporating Hydantoin Moieties Effectively Inhibit Eukaryoticand Human Carbonic Anhydrases
por: Abdoli, Morteza, et al.
Publicado: (2022)

Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails
por: Awadallah, Fadi M., et al.
Publicado: (2018)

Inhibition of bacterial α-, β- and γ-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties
por: Angeli, Andrea, et al.
Publicado: (2018)

Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani
por: Nocentini, Alessio, et al.
Publicado: (2019)

Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and in silico study
por: Othman, Dina I.A., et al.
Publicado: (2023)

S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors
por: El-Azab, Adel S., et al.
Publicado: (2020)

An overview on the recently discovered iota-carbonic anhydrases
por: Nocentini, Alessio, et al.
Publicado: (2021)

Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties
por: Tekeli, Tuba, et al.
Publicado: (2023)

4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors
por: Abdoli, Morteza, et al.
Publicado: (2022)

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors
por: Al-Sanea, Mohammad M., et al.
Publicado: (2019)

Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study
por: Abdel-Aziz, Alaa A.-M., et al.
Publicado: (2020)

Carbonic Anhydrase Inhibitors as Novel Antibacterials in the Era of Antibiotic Resistance: Where Are We Now?
por: Nocentini, Alessio, et al.
Publicado: (2023)

Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii
por: Del Prete, Sonia, et al.
Publicado: (2020)

Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy
por: Nocentini, Alessio, et al.
Publicado: (2020)

Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors
por: Oudah, Khulood H., et al.
Publicado: (2022)

The Effect of Substituted Benzene-Sulfonamides and Clinically Licensed Drugs on the Catalytic Activity of CynT2, a Carbonic Anhydrase Crucial for Escherichia coli Life Cycle
por: Del Prete, Sonia, et al.
Publicado: (2020)

Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry
por: Krasavin, Mikhail, et al.
Publicado: (2019)

Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors
por: Peerzada, Mudasir Nabi, et al.
Publicado: (2023)

Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII
por: Giovannuzzi, Simone, et al.
Publicado: (2022)

Benzylaminoethyureido-Tailed Benzenesulfonamides: Design, Synthesis, Kinetic and X-ray Investigations on Human Carbonic Anhydrases
por: Ali, Majid, et al.
Publicado: (2020)

Native mass spectrometry of human carbonic anhydrase I and its inhibitor complexes
por: Zoppi, Carlotta, et al.
Publicado: (2020)

Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies
por: Milite, Ciro, et al.
Publicado: (2019)

Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum
por: Giovannuzzi, Simone, et al.
Publicado: (2022)

Coumarins effectively inhibit bacterial α-carbonic anhydrases
por: Giovannuzzi, Simone, et al.
Publicado: (2022)

Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors
por: Giovannuzzi, Simone, et al.
Publicado: (2023)

Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles
por: Nocentini, Alessio, et al.
Publicado: (2017)

Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeae
por: Nocentini, Alessio, et al.
Publicado: (2021)

1,2,3-Benzoxathiazine-2,2-dioxides – effective inhibitors of human carbonic anhydrases
por: Ivanova, Jekaterina, et al.
Publicado: (2022)

3H-1,2-Benzoxaphosphepine 2-oxides as selective inhibitors of carbonic anhydrase IX and XII
por: Pustenko, Aleksandrs, et al.
Publicado: (2022)

Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms
por: Nocentini, Alessio, et al.
Publicado: (2018)

Extending the Inhibition Profiles of Coumarin-Based Compounds Against Human Carbonic Anhydrases: Synthesis, Biological, and In Silico Evaluation
por: Kartsev, Victor, et al.
Publicado: (2019)

Inhibition studies of bacterial α-carbonic anhydrases with phenols
por: Giovannuzzi, Simone, et al.
Publicado: (2022)

Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators
por: Nocentini, Alessio, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3n163rlbtrfhni86l16l2vvc46