A model for the dynamics of expanded CAG repeat alleles: ATXN2 and ATXN3 as prototypes

Background: Spinocerebellar ataxia types 2 (SCA2) and 3 (SCA3/MJD) are diseases due to dominant unstable expansions of CAG repeats (CAGexp). Age of onset of symptoms (AO) correlates with the CAGexp length. Repeat instability leads to increases in the expanded repeats, to important AO anticipations a...

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Detalles Bibliográficos
Autores principales: Sena, Lucas Schenatto, Lemes, Renan Barbosa, Furtado, Gabriel Vasata, Saraiva-Pereira, Maria Luiza, Jardim, Laura Bannach
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682950/
https://www.ncbi.nlm.nih.gov/pubmed/38034492
http://dx.doi.org/10.3389/fgene.2023.1296614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682950/
https://www.ncbi.nlm.nih.gov/pubmed/38034492
http://dx.doi.org/10.3389/fgene.2023.1296614

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