Cargando…

Treatment of Parkinson’s disease with biologics that penetrate the blood–brain barrier via receptor-mediated transport

Parkinson’s disease (PD) is characterized by neurodegeneration of nigral-striatal neurons in parallel with the formation of intra-neuronal α-synuclein aggregates, and these processes are exacerbated by neuro-inflammation. All 3 components of PD pathology are potentially treatable with biologics. Neu...

Descripción completa

Detalles Bibliográficos
Autor principal:	Pardridge, William M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682952/ https://www.ncbi.nlm.nih.gov/pubmed/38035276 http://dx.doi.org/10.3389/fnagi.2023.1276376

Ejemplares similares

Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain
por: Pardridge, William M.
Publicado: (2020)

Kinetics of Blood–Brain Barrier Transport of Monoclonal Antibodies Targeting the Insulin Receptor and the Transferrin Receptor
por: Pardridge, William M.
Publicado: (2021)

Peripheral inflammation promotes brain tau transmission via disrupting blood–brain barrier
por: Liu, Yanchao, et al.
Publicado: (2020)

Mathematical Models of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Transferrin Receptor and the Insulin Receptor
por: Pardridge, William M., et al.
Publicado: (2021)

Receptor-mediated drug delivery of bispecific therapeutic antibodies through the blood-brain barrier
por: Pardridge, William M.
Publicado: (2023)

Imaging blood–brain barrier disruption in neuroinflammation and Alzheimer’s disease
por: Lee, Rae-Ling, et al.
Publicado: (2023)

Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging
por: Ford, Jeremy N., et al.
Publicado: (2022)

Editorial: Imaging of the blood-brain barrier in Alzheimer's disease and related disorders
por: Uchida, Yuto, et al.
Publicado: (2023)

Blood-brain barrier dysfunction and Alzheimer’s disease: associations, pathogenic mechanisms, and therapeutic potential
por: Chen, Yanting, et al.
Publicado: (2023)

Contributions of blood–brain barrier imaging to neurovascular unit pathophysiology of Alzheimer’s disease and related dementias
por: Uchida, Yuto, et al.
Publicado: (2023)

Neuroprotective effect of Dl-3-n-butylphthalide against ischemia–reperfusion injury is mediated by ferroptosis regulation via the SLC7A11/GSH/GPX4 pathway and the attenuation of blood–brain barrier disruption
por: Xu, Shuangli, et al.
Publicado: (2023)

Acupuncture Regulates Symptoms of Parkinson’s Disease via Brain Neural Activity and Functional Connectivity in Mice
por: Oh, Ju-Young, et al.
Publicado: (2022)

Severe Hypoglycemia Contributing to Cognitive Dysfunction in Diabetic Mice Is Associated With Pericyte and Blood–Brain Barrier Dysfunction
por: Lin, Lu, et al.
Publicado: (2021)

Preserved blood-brain barrier and neurovascular coupling in female 5xFAD model of Alzheimer’s disease
por: Zhukov, Oleg, et al.
Publicado: (2023)

Treatment of CLN1 disease with a blood-brain barrier penetrating lysosomal enzyme
por: Hahn, Andreas, et al.
Publicado: (2022)

Bibliometric analysis of research topics on blood–brain barrier breakdown and cognitive function over the last two decades (2000–2021)
por: Zhang, Ruirui, et al.
Publicado: (2023)

Treatment of Alzheimer’s Disease and Blood–Brain Barrier Drug Delivery
por: Pardridge, William M.
Publicado: (2020)

Advanced Blood–Brain Barrier Drug Delivery
por: Pardridge, William M.
Publicado: (2022)

Insulin Receptor Antibody–Sulfamidase Fusion Protein Penetrates the Primate Blood–Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type A Cells
por: Boado, Ruben J., et al.
Publicado: (2014)

Sex Differences in Brain and Cognition in de novo Parkinson's Disease
por: Oltra, Javier, et al.
Publicado: (2022)

Structural Brain Network Abnormalities in Parkinson’s Disease With Freezing of Gait
por: Jin, Chaoyang, et al.
Publicado: (2022)

Morphologic brain network predicts levodopa responsiveness in Parkinson disease
por: Xie, Yongsheng, et al.
Publicado: (2023)

Brain Surface Area Alterations Correlate With Gait Impairments in Parkinson’s Disease
por: Wei, Xuan, et al.
Publicado: (2022)

The Pathological Mechanism Between the Intestine and Brain in the Early Stage of Parkinson's Disease
por: Yang, Runing, et al.
Publicado: (2022)

Alzheimer's disease pathology: pathways between chronic vascular risk factors and blood-brain barrier dysfunction in a cohort of patients with different types of dementia
por: Gan, Jinghuan, et al.
Publicado: (2023)

Drug transport in brain via the cerebrospinal fluid
por: Pardridge, William M
Publicado: (2011)

Exploring brain changes of impulse control disorders in Parkinson's disease: An ALE study
por: Gu, Lihua, et al.
Publicado: (2022)

The impact of iron deposition on the fear circuit of the brain in patients with Parkinson’s disease and anxiety
por: Chen, Kaidong, et al.
Publicado: (2023)

The Isolated Brain Microvessel: A Versatile Experimental Model of the Blood-Brain Barrier
por: Pardridge, William M.
Publicado: (2020)

Commentary: The impact of iron deposition on the fear circuit of the brain in patients with Parkinson's disease and anxiety
por: Chen, Leilei, et al.
Publicado: (2023)

Altered Prefrontal Blood Flow Related With Mild Cognitive Impairment in Parkinson's Disease: A Longitudinal Study
por: Wang, Jian, et al.
Publicado: (2022)

Cell–Cell Communication Alterations via Intercellular Signaling Pathways in Substantia Nigra of Parkinson’s Disease
por: Huang, Maoxin, et al.
Publicado: (2022)

IgG Fusion Proteins for Brain Delivery of Biologics via Blood–Brain Barrier Receptor-Mediated Transport
por: Boado, Ruben J.
Publicado: (2022)

New Understanding on the Pathophysiology and Treatment of Constipation in Parkinson’s Disease
por: Xu, Jianli, et al.
Publicado: (2022)

Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier
por: Kopel, Jonathan J., et al.
Publicado: (2021)

Soluble Triggering Receptor Expressed on Myeloid Cells 2 From Cerebrospinal Fluid in Sleep Disorders Related to Parkinson’s Disease
por: Mo, Mingshu, et al.
Publicado: (2021)

High resolution 16S rRNA gene Next Generation Sequencing study of brain areas associated with Alzheimer’s and Parkinson’s disease
por: Emery, David C., et al.
Publicado: (2022)

The efficacy and safety of asleep and awake subthalamic deep brain stimulation for Parkinson’s disease patients: A 1-year follow-up
por: Chen, Wanru, et al.
Publicado: (2023)

Machine learning models for diagnosis and prognosis of Parkinson's disease using brain imaging: general overview, main challenges, and future directions
por: Garcia Santa Cruz, Beatriz, et al.
Publicado: (2023)

Modulations of bioactive lipids and their receptors in postmortem Alzheimer’s disease brains
por: Kurano, Makoto, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_e5faoudeqmg33vldvo51bg7gja