Diester Prodrugs of a Phosphonate Butyrophilin Ligand Display Improved Cell Potency, Plasma Stability, and Payload Internalization

[Image: see text] Activation of Vγ9Vδ2 T cells with butyrophilin 3A1 (BTN3A1) agonists such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) has the potential to boost the immune response. Because HMBPP is highly charged and metabolically unstable, prodrugs may be needed to overcome these li...

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Detalles Bibliográficos
Autores principales: Singh, Umed, Pawge, Girija, Rani, Sarita, Hsiao, Chia-Hung Christine, Wiemer, Andrew J., Wiemer, David F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683022/
https://www.ncbi.nlm.nih.gov/pubmed/37934915
http://dx.doi.org/10.1021/acs.jmedchem.3c01358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683022/
https://www.ncbi.nlm.nih.gov/pubmed/37934915
http://dx.doi.org/10.1021/acs.jmedchem.3c01358

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