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Stereoselective Synthesis, Pro-resolution, and Anti-inflammatory Actions of RvD5(n-3 DPA)

[Image: see text] The methyl ester of resolvin D5(n-3 DPA), a lipid mediator biosynthesized from the omega-3 fatty acid n-3 docosapentaenoic acid, was stereoselectively prepared in 8% yield over 12 steps (longest linear sequence). The key steps for the introduction of the two stereogenic secondary a...

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Detalles Bibliográficos
Autores principales: Ervik, Karina, Reinertsen, Amalie F., Koenis, Duco S., Dalli, Jesmond, Hansen, Trond V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683074/
https://www.ncbi.nlm.nih.gov/pubmed/37879110
http://dx.doi.org/10.1021/acs.jnatprod.3c00769