Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a profoundly aggressive and fatal cancer. One of the key factors defining its aggressiveness and resilience against chemotherapy is the existence of cancer stem cells (CSCs). The important task of discovering upstream regulators of stemness that...

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Detalles Bibliográficos
Autores principales: Zheng, Quan, Tang, Jiajia, Aicher, Alexandra, Bou Kheir, Tony, Sabanovic, Berina, Ananthanarayanan, Preeta, Reina, Chiara, Chen, Minchun, Gu, Jian-Min, He, Bin, Alcala, Sonia, Behrens, Diana, Lawlo, Rita T., Scarpa, Aldo, Hidalgo, Manuel, Sainz, Bruno, Sancho, Patricia, Heeschen, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683265/
https://www.ncbi.nlm.nih.gov/pubmed/38012687
http://dx.doi.org/10.1186/s13046-023-02883-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683265/
https://www.ncbi.nlm.nih.gov/pubmed/38012687
http://dx.doi.org/10.1186/s13046-023-02883-y

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