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Modular bioengineering of whole-cell catalysis for sialo-oligosaccharide production: coordinated co-expression of CMP-sialic acid synthetase and sialyltransferase
BACKGROUND: In whole-cell bio-catalysis, the biosystems engineering paradigm shifts from the global reconfiguration of cellular metabolism as in fermentation to a more focused, and more easily modularized, optimization of comparably short cascade reactions. Human milk oligosaccharides (HMO) constitu...
Autores principales: | Schelch, Sabine, Eibinger, Manuel, Zuson, Jasmin, Kuballa, Jürgen, Nidetzky, Bernd |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683312/ https://www.ncbi.nlm.nih.gov/pubmed/38012629 http://dx.doi.org/10.1186/s12934-023-02249-1 |
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