Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signaling pathway

BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) is one of the main reasons for poor prognosis in patients with ischemic cardiomyopathy (ICM). To date, the mechanism remains unknown. As members of the silent information regulator 2 (SIR2) family, both SIRT1 and SIRT3 have been shown to play...

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Detalles Bibliográficos
Autores principales: Liao, Yunfei, Ke, Ben, Long, Xiaoyan, Xu, Jianjun, Wu, Yongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683361/
https://www.ncbi.nlm.nih.gov/pubmed/38012584
http://dx.doi.org/10.1186/s12872-023-03603-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683361/
https://www.ncbi.nlm.nih.gov/pubmed/38012584
http://dx.doi.org/10.1186/s12872-023-03603-2

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