Deep Learning-Driven Library Design for the De Novo Discovery of Bioactive Thiopeptides

[Image: see text] Broad substrate tolerance of ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic enzymes has allowed numerous strategies for RiPP engineering. However, despite relaxed specificities, exact substrate preferences of RiPP enzymes are often difficult t...

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Detalles Bibliográficos
Autores principales: Chang, Jun Shi, Vinogradov, Alexander A., Zhang, Yue, Goto, Yuki, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683472/
https://www.ncbi.nlm.nih.gov/pubmed/38033794
http://dx.doi.org/10.1021/acscentsci.3c00957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683472/
https://www.ncbi.nlm.nih.gov/pubmed/38033794
http://dx.doi.org/10.1021/acscentsci.3c00957

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