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Deep Learning-Driven Library Design for the De Novo Discovery of Bioactive Thiopeptides
[Image: see text] Broad substrate tolerance of ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic enzymes has allowed numerous strategies for RiPP engineering. However, despite relaxed specificities, exact substrate preferences of RiPP enzymes are often difficult t...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683472/ https://www.ncbi.nlm.nih.gov/pubmed/38033794 http://dx.doi.org/10.1021/acscentsci.3c00957 |