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Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network-inferred activity
Gene regulatory networks (GRNs) are often deregulated in tumor cells, resulting in altered transcriptional programs that facilitate tumor growth. These altered networks may make tumor cells vulnerable to the inhibition of specific regulatory proteins. Consequently, the reconstruction of GRNs in tumo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683780/ https://www.ncbi.nlm.nih.gov/pubmed/38035131 http://dx.doi.org/10.1093/narcan/zcad056 |