Rapamycin downregulates α-klotho in the kidneys of female rats with normal and reduced renal function

Both mTOR and α-klotho play a role in the pathophysiology of renal disease, influence mineral metabolism and participate in the aging process. The influence of mTOR inhibition by rapamycin on renal α-klotho expression is unknown. Rats with normal (controls) and reduced (Nx) renal function were treat...

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Detalles Bibliográficos
Autores principales: Espartero, Azahara, Vidal, Angela, Lopez, Ignacio, Raya, Ana I., Rodriguez, Mariano, Aguilera-Tejero, Escolastico, Pineda, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684065/
https://www.ncbi.nlm.nih.gov/pubmed/38015969
http://dx.doi.org/10.1371/journal.pone.0294791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684065/
https://www.ncbi.nlm.nih.gov/pubmed/38015969
http://dx.doi.org/10.1371/journal.pone.0294791

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