A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a global health crisis. The virus can cause varying severity of liver injury, but the mechanism has not yet been elucidated, especially in pregnancy. We present a morbidly obese 30-year-old wom...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Medical Publishers, Inc.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684339/ https://www.ncbi.nlm.nih.gov/pubmed/38033600 http://dx.doi.org/10.1055/s-0043-1777099 |
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author | Berger, Dana Senderoff Galyean, Anna Nguyen, Kelvin Alshak, Najeeb Blumenthal, Elizabeth |
author_facet | Berger, Dana Senderoff Galyean, Anna Nguyen, Kelvin Alshak, Najeeb Blumenthal, Elizabeth |
author_sort | Berger, Dana Senderoff |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a global health crisis. The virus can cause varying severity of liver injury, but the mechanism has not yet been elucidated, especially in pregnancy. We present a morbidly obese 30-year-old woman with COVID-19 at 28 weeks' gestation complicated by significant transaminitis with peak liver enzymes levels of 501/1,313 (aspartate aminotransferase/alanine aminotransferase). Liver biopsy showed reactive changes consistent with medication effect and mild steatosis. Significant transaminitis has been found in both pregnant and nonpregnant patients with COVID-19. Our case demonstrates the multifactorial nature of liver injury in COVID-19 patients including mild underlying liver steatosis combined with possible viral potentiation of medication effect. |
format | Online Article Text |
id | pubmed-10684339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Thieme Medical Publishers, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106843392023-11-30 A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19 Berger, Dana Senderoff Galyean, Anna Nguyen, Kelvin Alshak, Najeeb Blumenthal, Elizabeth AJP Rep Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a global health crisis. The virus can cause varying severity of liver injury, but the mechanism has not yet been elucidated, especially in pregnancy. We present a morbidly obese 30-year-old woman with COVID-19 at 28 weeks' gestation complicated by significant transaminitis with peak liver enzymes levels of 501/1,313 (aspartate aminotransferase/alanine aminotransferase). Liver biopsy showed reactive changes consistent with medication effect and mild steatosis. Significant transaminitis has been found in both pregnant and nonpregnant patients with COVID-19. Our case demonstrates the multifactorial nature of liver injury in COVID-19 patients including mild underlying liver steatosis combined with possible viral potentiation of medication effect. Thieme Medical Publishers, Inc. 2023-11-28 /pmc/articles/PMC10684339/ /pubmed/38033600 http://dx.doi.org/10.1055/s-0043-1777099 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Berger, Dana Senderoff Galyean, Anna Nguyen, Kelvin Alshak, Najeeb Blumenthal, Elizabeth A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19 |
title | A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19 |
title_full | A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19 |
title_fullStr | A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19 |
title_full_unstemmed | A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19 |
title_short | A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19 |
title_sort | case of significant transaminitis with liver biopsy in a pregnant patient with covid-19 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684339/ https://www.ncbi.nlm.nih.gov/pubmed/38033600 http://dx.doi.org/10.1055/s-0043-1777099 |
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