A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a global health crisis. The virus can cause varying severity of liver injury, but the mechanism has not yet been elucidated, especially in pregnancy. We present a morbidly obese 30-year-old wom...

Descripción completa

Detalles Bibliográficos
Autores principales: Berger, Dana Senderoff, Galyean, Anna, Nguyen, Kelvin, Alshak, Najeeb, Blumenthal, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical Publishers, Inc. 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684339/
https://www.ncbi.nlm.nih.gov/pubmed/38033600
http://dx.doi.org/10.1055/s-0043-1777099
_version_ 1785151381381840896
author Berger, Dana Senderoff
Galyean, Anna
Nguyen, Kelvin
Alshak, Najeeb
Blumenthal, Elizabeth
author_facet Berger, Dana Senderoff
Galyean, Anna
Nguyen, Kelvin
Alshak, Najeeb
Blumenthal, Elizabeth
author_sort Berger, Dana Senderoff
collection PubMed
description Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a global health crisis. The virus can cause varying severity of liver injury, but the mechanism has not yet been elucidated, especially in pregnancy. We present a morbidly obese 30-year-old woman with COVID-19 at 28 weeks' gestation complicated by significant transaminitis with peak liver enzymes levels of 501/1,313 (aspartate aminotransferase/alanine aminotransferase). Liver biopsy showed reactive changes consistent with medication effect and mild steatosis. Significant transaminitis has been found in both pregnant and nonpregnant patients with COVID-19. Our case demonstrates the multifactorial nature of liver injury in COVID-19 patients including mild underlying liver steatosis combined with possible viral potentiation of medication effect.
format Online
Article
Text
id pubmed-10684339
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Thieme Medical Publishers, Inc.
record_format MEDLINE/PubMed
spelling pubmed-106843392023-11-30 A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19 Berger, Dana Senderoff Galyean, Anna Nguyen, Kelvin Alshak, Najeeb Blumenthal, Elizabeth AJP Rep Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a global health crisis. The virus can cause varying severity of liver injury, but the mechanism has not yet been elucidated, especially in pregnancy. We present a morbidly obese 30-year-old woman with COVID-19 at 28 weeks' gestation complicated by significant transaminitis with peak liver enzymes levels of 501/1,313 (aspartate aminotransferase/alanine aminotransferase). Liver biopsy showed reactive changes consistent with medication effect and mild steatosis. Significant transaminitis has been found in both pregnant and nonpregnant patients with COVID-19. Our case demonstrates the multifactorial nature of liver injury in COVID-19 patients including mild underlying liver steatosis combined with possible viral potentiation of medication effect. Thieme Medical Publishers, Inc. 2023-11-28 /pmc/articles/PMC10684339/ /pubmed/38033600 http://dx.doi.org/10.1055/s-0043-1777099 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Berger, Dana Senderoff
Galyean, Anna
Nguyen, Kelvin
Alshak, Najeeb
Blumenthal, Elizabeth
A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
title A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
title_full A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
title_fullStr A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
title_full_unstemmed A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
title_short A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
title_sort case of significant transaminitis with liver biopsy in a pregnant patient with covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684339/
https://www.ncbi.nlm.nih.gov/pubmed/38033600
http://dx.doi.org/10.1055/s-0043-1777099
work_keys_str_mv AT bergerdanasenderoff acaseofsignificanttransaminitiswithliverbiopsyinapregnantpatientwithcovid19
AT galyeananna acaseofsignificanttransaminitiswithliverbiopsyinapregnantpatientwithcovid19
AT nguyenkelvin acaseofsignificanttransaminitiswithliverbiopsyinapregnantpatientwithcovid19
AT alshaknajeeb acaseofsignificanttransaminitiswithliverbiopsyinapregnantpatientwithcovid19
AT blumenthalelizabeth acaseofsignificanttransaminitiswithliverbiopsyinapregnantpatientwithcovid19
AT bergerdanasenderoff caseofsignificanttransaminitiswithliverbiopsyinapregnantpatientwithcovid19
AT galyeananna caseofsignificanttransaminitiswithliverbiopsyinapregnantpatientwithcovid19
AT nguyenkelvin caseofsignificanttransaminitiswithliverbiopsyinapregnantpatientwithcovid19
AT alshaknajeeb caseofsignificanttransaminitiswithliverbiopsyinapregnantpatientwithcovid19
AT blumenthalelizabeth caseofsignificanttransaminitiswithliverbiopsyinapregnantpatientwithcovid19