USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice

The USP19 deubiquitinase is found in a locus associated with Parkinson’s Disease (PD), interacts with chaperonins, and promotes secretion of α-synuclein (α-syn) through the misfolding-associated protein secretion (MAPS) pathway. Since these processes might modulate the processing of α-syn aggregates...

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Detalles Bibliográficos
Autores principales: Schorova, Lenka, Bedard, Nathalie, Khayachi, Anouar, Ho, Hung-Hsiang, Bolivar-Pedroso, Joao, Huynh, Julie, Piccirelli, Mikaela, Wang, Yifei, Plourde, Marie, Luo, Wen, del Cid-Pellitero, Esther, Shlaifer, Irina, Castellanos-Montiel, María José, Yu, Ziqi, Valenzuela, Dulce Valeria Carrillo, Lacalle-Aurioles, María, Kriz, Anita, Ye, Yihong, Durcan, Thomas M., Wing, Simon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684503/
https://www.ncbi.nlm.nih.gov/pubmed/38017009
http://dx.doi.org/10.1038/s41531-023-00601-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684503/
https://www.ncbi.nlm.nih.gov/pubmed/38017009
http://dx.doi.org/10.1038/s41531-023-00601-1

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