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Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens

Accumulating evidence indicates that HOXA9 dysregulation is necessary and sufficient for leukemic transformation and maintenance. However, it remains largely unknown how HOXA9, as a homeobox transcriptional factor, binds to noncoding regulatory sequences and controls the downstream genes. Here, we c...

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Detalles Bibliográficos
Autores principales: Wright, Shaela, Zhao, Xujie, Rosikiewicz, Wojciech, Mryncza, Shelby, Hyle, Judith, Qi, Wenjie, Liu, Zhenling, Yi, Siqi, Cheng, Yong, Xu, Beisi, Li, Chunliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684515/
https://www.ncbi.nlm.nih.gov/pubmed/38016946
http://dx.doi.org/10.1038/s41467-023-43264-5