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Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens
Accumulating evidence indicates that HOXA9 dysregulation is necessary and sufficient for leukemic transformation and maintenance. However, it remains largely unknown how HOXA9, as a homeobox transcriptional factor, binds to noncoding regulatory sequences and controls the downstream genes. Here, we c...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684515/ https://www.ncbi.nlm.nih.gov/pubmed/38016946 http://dx.doi.org/10.1038/s41467-023-43264-5 |